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Excessive sedation is the most frequent cause of animal death during air travel, according to a study published in the Journal of AVMA.

In some cases it’s simple, as when a calm animal can be easily left in a comfy crate for long stretches at a time. After all, pets need a chance to heal and most won’t comply without physical restrictions on their often injurious behavior. Crazy bouncy Labs, loudmouth crate barkers, separation anxiety cases, silly little kittens and pets who require long recoveries after orthopedic surgery, for example. Here’s one story that highlights how things can go terribly wrong when owners don’t comply: After a puppy with a nasty open fracture was unceremoniously “dumped” at our hospital a few years back, I took it upon myself to beg free services off my vet surgeon boyfriend and foster her at home during her recovery. Though he settles quickly, the potential for damage is high.In these situations, sedatives reduce the potential for self-injury. Even nervous pets, once they are in a carrier in a quiet dark place, typically calm down and most even go to sleep.The primary disadvantage of sedating pets for air travel is that there is no one to check on them nor offer medical care if problems arise. The most profound and potentially life threatening problem associated with sedation is the effect on blood pressure.After the initial excitement of the trip to the airport and handling during loading, the dog might revert to a quiet resting state in the dark cargo hold. Use conditioning – not chemicals – for safe travel, says Victoria Lukasik, DVM, a board-certified veterinary anesthesiologist.“Tranquilizers, the most popular being acepromazine, interfere with cardiac function and promote heat loss,” Lukasik says.

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